![]() This technology allows the delivery of DNA to target cells to achieve the expression of a protective or therapeutic protein and also in neurodegenerative diseases, including Alzheimer’s disease (AD). Recent advances in the field of gene transfer technology have allowed the delivery of DNA into target cells of the recipient based on the use of viral systems for gene therapy. Both gene therapy and cell based therapy may be feasible therapeutic approaches for human AD. Here we review the current utilization of APPswe/PS1dE9 mice in testing gene transfer and cell transplantation aimed at improving the protection of the neurons against A β toxicity and also reducing the brain levels of A β. As gene transfer technology allows the delivery of DNA into target cells to achieve the expression of a protective or therapeutic protein, and stem cell transplantation may create an environment supporting neuronal functions and clearing A β plaques, these therapeutic approaches alone or in combination represent potential therapeutic strategies that need to be tested in relevant animal models before testing in clinics. These mice show increase in parenchymal A β load with A β plaques starting from the age of four months, glial activation, and deficits in cognitive functions at the age of 6 months demonstrated by radial arm water maze and 12-13 months seen with Morris Water Maze test. Wild 9 is one of those games that purports to have a unique concept behind it, yet falls flat in its implementation.One of the most extensively used transgenic mouse model of Alzheimer’s disease (AD) is APPswe/PS1dE9 mice, which over express the Swedish mutation of APP together with PS1 deleted in exon 9. The bosses and flying levels break up the basic gameplay nicely, but the parts that connect in between those are dull. Really, bashing an enemy against an obstacle multiple times turns old after the first few tries, especially with the rig controls being as loose as they are. The whole play mechanic of using the rig to move objects and enemies about may seem pretty interesting at first, but soon gets rather tiring. Luckily, the game can be played with the sound turned all the way down without affecting play.īut all of those detractions could be ancillary with decent gameplay, but in this case it doesn't save the rest of the game. Delivered in a nasal surfer tone that makes people think disparaging things about California, the main character's comments sound like a 40-year-old ad exec's idea of what "the kids" think is "cool" "these days." "Wex-cellent?" Please. ![]() The voice-overs also detract from the audio side, being some of the most abrasive heard in a long time. At worst, it demands your attention with crescendos of gut-wrenching cheese '80s power chords. Wex, for example, stomps through the game like a big-booted ogre galloping through that cheapo '80s Tom & Jerry cartoon series.Īt best, Wild 9's soundtrack is an easily ignorable background element. The animation also seems clunky and basic for all the characters, except the bosses. The graphics in Wild 9 look like a mix of Pandemonium and Pitfall 3D: Beyond the Jungle, giving it a pretty dated appearance, save for some more modern-looking backgrounds. Otherwise, it's pretty standard platform-game fare, with running, jumping, and occasionally shooting. There are also instances where you have to harness keys and other items with the device as well. This is actually a large part of the gameplay, as you have to destroy obstacles (propellers, electric signs, flame spouts, etc.) using your opponents' bodies as clubs or, other times, spill them into a spiked pit so that you can use them as a stepping stone to pass by unscathed. This comes into play mostly when confronting enemies, whom Wex can beat into the ground by snagging and throwing them with the beam, dropping them into grinders, and so on. ![]() To help you on this quest is a device called the rig and the glove, which allows Wex to grab objects using an extended energy beam and slam them about or swing along. Your goal is to travel from planet to planet within this star system, freeing the members of the rebel group you've fallen in with, the Wild 9 (which includes Nitro, the human bomb the voluminous Volstagg the many-pocketed Pokkit and five others), and then destroying Karn. The latest platform game from the house that Earthworm Jim built puts you in the shoes of Wex Major, a teenage boy who lands far away from home, into a galaxy enslaved by the evil overlord Karn.
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